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Year
2007
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Sildenafil Improves Depression in Men With Erectile Dysfunction: Presented at CPA
November 15, 2006
Men with erectile dysfunction (ED) and depression reported an improvement in both their depression and quality of life when successfully treated with sildenafil for their ED, according to research reported here in a poster presentation at the 56th Annual Meeting of the Canadian Psychiatric Association (CPA).
Many men with erectile dysfunction also experience some symptoms of depression and decreased quality of life, said investigator Sidney H Kennedy, MD, professor of psychiatry and head, Mood and Anxiety Disorders Program, University of Toronto, Toronto, Ontario, Canada.
Dr. Kennedy and colleagues therefore conducted a study to assess the effect of sildenafil on untreated depression in men with ED. Patients in the study met the Diagnostic and Statistical Manual - Revision IV criteria for dysthymia or depression, including minor depressive disorder but excluding any form of major depressive or psychotic disorder.
The 6-week, double-blind, randomized, placebo-controlled study enrolled men with ED and a Beck Depression Inventory (BDI) II score of 14 to 28. The effect of treatment on the depressive symptoms was assessed with the BDI II and ED was measured with standard psychiatric questionnaires. Quality of life (QOL) was measured with the Patient Reported Erectile Function Assessment (PREFA).
The study group consisted of 185 men with an average age of 51 years. Mean BDI II scores at baseline were 18.33 for placebo and 17.99 for the sildenafil group. The duration of depression was 3.32 years for the placebo group and 3.08 years for the sildenafil group. ED duration was 3.79 years and 4.06 years, respectively.
Read the complete study here:
http://www.docguide.com/news/content.nsf/news/852571020057CCF685257227004CEFC5
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