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Dapoxetine: Drug for
Premature Ejaculation 
A new drug application for dapoxetine
is currently under review by the U.S. Food and Drug Administration
(FDA), and if approved, it will be the first prescription
product indicated for the treatment of...
Distribution Source : Viagracures.com
Date : June 2, 2005
A new drug application for dapoxetine is
currently under review by the U.S. Food
and Drug Administration (FDA), and if approved, it will
be the first prescription product indicated for the treatment
of Premature Ejaculation. As said by Dr. Jon Pryor, professor
and chairman of the department of urological surgery at
the University of Minnesota's Cities campus in Minneapolis
"Premature Ejaculation is the most common male sexual
dysfunction and about 20 percent of adult males have premature
ejaculation at any one time, and 70 percent of men experience
premature ejaculation at some time during their lives."
This new drug is meant to treat premature ejaculation and
it's estimated that it could make a bigger impact on the
male sexual health market than Pfizer's
impotence blockbuster Viagra.
As compared to erectile
dysfunction it has been estimated that PE may effect
27% to 34% of man across all age ranges, while ED is estimated
to affect 10% to 12% of all men, who are usually older than
age. Although PE is common it still remains widely under-diagnosed
and under-treated.
As soon as dapoxetine receives FDA approval, the potential
market for it is huge, though doctors said that it depends
on other factors. "Mainly a lot will depend on how
aggressively the company will use direct to consumer advertising
for PE" said Dr. Jonathan Jarow, Professor of Urology.
He said that other drugs in the same class as dapoxetine
are now prescribed by doctors for premature ejaculation
and are recognized by the American Urological Association
as treatments of the condition, but prescriptions of these
medications- called selective serotonin- are for off label
use and cannot be advertised.
Researchers took 2614 men with PE and followed them for
12 weeks. The men were instructed to take a pill 1 to 3
hours before they planned to have sex. Though they didn't
know it, some of the men were taking dapoxetine while others
were taking a dummy pill, or placebo. Their partners-women--held
a stopwatch to time the period between penetration and orgasm.
The men taking the placebo increased their time to ejaculation
from about one minute to just less than two minutes, on
average. The real drug, however, had a bigger effect. Men
who took 30 mg. of dapoxetine held off their orgasm for
nearly three minutes. Men on a 60 mg. dose did so for about
three and a half minutes. A lot more men taking the drug
rated their feelings of satisfaction as good or very good."
The big increase was in sexual satisfaction rather being
focused on time and only time."
The percentage of men rating control over ejaculation as
"fair to very good" increased dramatically for
dapoxetine 30 mg (2.5% to 51.8%) and 60 mg (3.3% to 58.4%)
compared to placebo (3.5% to 26.4%).
The percentage of men rating sexual satisfaction as "good
to very good" almost doubled with dapoxetine 30 mg
(20.2% to 38.7%) and 60 mg (22.3% to 46.5%), respectively,
in comparison to placebo (21.6% to 24.6%).
The percentage of partners rating sexual satisfaction as
"good to very good" almost doubled with dapoxetine
30 mg (20.4% to 39%) and 60 mg (24.8% to 47.4%), respectively,
compared to placebo (20.1% to 25.2%).
Dapoxetine can be taken as needed, just a few hours before
a person plans to have sex, so it is relatively convenient.
Other drugs-antidepressants-used to treat PE need to be
taken continuously. Now one can comfortably get the pill
from a general physician rather that going to a sex therapist.
But there are some cautions as the drug isn't approved
yet it is still waiting for FDA approval. The drug has side
effects: 20 percent of men taking the higher dosage reported
feeling nauseous. And many psychologists believe that the
drug alone is not enough, it will work best paired with
therapy to deal with feelings of inadequacy or anxiety that
may contribute to PE.
