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The big discovery, the Cyclic Guanosine Monophosphate (cGMP), the key to sustaining an erection, earned the scientists the Nobel Prize...

Distribution Source : Viagracures.com
Date : August 04, 2006

The big discovery, the Cyclic Guanosine Monophosphate (cGMP), the key to sustaining an erection, earned the scientists the Nobel Prize.

It was found, that, when a man gets sexually stimulated, a chain reaction occurs in the tissue of the penis, which results in elevated levels of a substance called cyclic guanosine phosphate As long as there are sufficient levels of cGMP, the penis can remain erect. The more the cGMP, more robust and longer erection is maintained.

PDE5 (Phosphodiesterase 5) is an enzyme that accepts cGMP and breaks it down and is responsible for the neutralization of cGMP. Pfizer found a chemical that could inhibit PDE5 from doing its job. This was called Sildenafil Citrate or the Viagra. Another way one can think of Viagra is that it preserves the elevated levels of cGMP that are created when a man is sexually stimulated for a stronger, more lasting erection.

When a man takes Viagra pill, the sildenafil citrate flows throughout the body but affects only the PDE5 enzyme in the penis. The drug stays in the blood stream for about 4 hrs. and then it is washed out of blood by liver and kidney.

Viagra is a member of a family of drugs called PDE 5 inhibitors. The nice things about the PDE5 blockers are that they don't cause erections at inappropriate times because they block degradation of cGMP produced in reaction to sexual stimulation. If one is not sexually stimulated, there is no cGMP to protect, so the drug remains in the background.

Viagra was the first PDE 5 inhibitors to be launched in the market. There were initial concerns of cardiovascular deaths, but however with time it has been proved that it is extremely safe when used correctly. Viagra has been in the market for number of years and has been used by millions of men in the world.

Levitra was the second to Viagra in the treatment of erectile Dysfunction. It works faster and have shown to be more effective in hard to treat patients.

All these are prescription drugs and are available online. Cheap Viagra, buy Viagra online sites or any other PDE5 blockers all are available online on a number of sites.